{"id":19,"date":"2024-07-25T05:53:22","date_gmt":"2024-07-25T05:53:22","guid":{"rendered":"https:\/\/jodasexpoim.in\/news\/?p=19"},"modified":"2026-06-12T11:33:52","modified_gmt":"2026-06-12T11:33:52","slug":"advent-of-chimeric-antigen-receptor-t-cell-car-t-celltherapy-offering-hope-for-cancer-patients","status":"publish","type":"post","link":"https:\/\/jodasexpoim.in\/news\/advent-of-chimeric-antigen-receptor-t-cell-car-t-celltherapy-offering-hope-for-cancer-patients\/","title":{"rendered":"Advent of Chimeric Antigen Receptor-T Cell (Car-T Cell)Therapy: Offering Hope for Cancer Patients"},"content":{"rendered":"<p>Cancer cases in India are expected to rise 12.8% by 2025 due to mutations in genes that impact, protein expression, and alter cells. Chimeric Antigen Receptor T cells (CAR-T) are genetically modified fusion proteins that can be expressed and transfused into patients. CAR-redirected T cells offer a promising cell-based immunotherapy method that can enhance and maintain antitumor GVL response without major histocompatibility complex restriction. The structure of CARs includes an intracellular signaling domain, a transmembrane domain, and an extracellular domain. The importance of single-chain variable fragment (scFv) in CAR-T cell therapy is due to their complete antigen-binding capability, which allows for faster and more even penetration to tumors and other tissues. Five generations of CAR-T cells have been created since 1989, with the first generation having limited expansion and persistence due to lack of a costimulatory signal. The manufacturing process for CAR T cells involves stimulating, transducing, expanding, and cryopreserving T cells under Good Manufacturing Practices conditions. This blog describes the evolution and brief applications of approved CART cell therapy.<\/p>\n<p><a class=\"cmn-btn\" href=\"https:\/\/jodasexpoim.in\/news\/wp-content\/uploads\/2026\/05\/Advent_of_Chimeric_Antigen_Receptor.pdf\" target=\"_blank\" rel=\"noopener\">Read More<i><img decoding=\"async\" src=\"https:\/\/jodasexpoim.in\/news\/wp-content\/themes\/jodas-expoim\/images\/blue-top-arrw.svg\" alt=\"Arrow\" \/><\/i><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer cases in India are expected to rise 12.8% by 2025 due to mutations in genes that impact protein expression, and alter cells. Chimeric Antigen Receptor T cells (CAR-T) are genetically modified&#8230;<\/p>\n","protected":false},"author":1,"featured_media":270,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-19","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oncology"],"acf":[],"_links":{"self":[{"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/posts\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":5,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/posts\/19\/revisions"}],"predecessor-version":[{"id":218,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/posts\/19\/revisions\/218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/media\/270"}],"wp:attachment":[{"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/media?parent=19"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/categories?post=19"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jodasexpoim.in\/news\/wp-json\/wp\/v2\/tags?post=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}