Complex Injectables

Complex InjectablesA complex injectable is a product that has a complex active ingredient (Complex mixture of active pharmaceutical ingredients (APIs), polymeric compounds, peptides), complex formulations (Liposomes. Nano-suspensions, Nano-emulsions, Microspheres etc), complex route of delivery (Locally acting such as dermatological and inhalational drugs), or complex drug-device combinations. (reference: https://www.fda.gov/media/108937/download) Complex injectables have gained increasing attention due to their advantage in applications in both acute and chronic diseases treatments. Particularly, suspensions and lipid-based nanoparticles are being increasingly utilized due to their ability to increase drug loading to improve bioavailability/stability and to enable long-acting injectable of poorly soluble drugs and biological/peptides. Advantages of complex injectables over conventional drug delivery system include:

  • Controlled delivery of API by maintaining desired drug concentration at the therapeutic site.
  • Accurate dosing.
  • Enhanced efficacy and safety.
  • Site/Target-specific delivery of drug with an optimum dose.
  • Decreased toxicity/side effects.
  • Improved patient compliance.

We, at Jodas, have developed and manufactured complex injectable in GMP condition – complex API (PEGASPARGASE) and several complex formulations like liposomes (Amphotericin B liposome for injection; Doxorubicin liposome Injection etc); Nanoparticles/Nanosuspension (Paclitaxel protein-bound particles for injectable suspension, Paliperidone palmitate extended release injectable suspension etc.); Nano-emulsions (propofol injection); Microspheres (Leuprolide acetate for depot suspension, Octreotide acetate for injectable suspension etc).

  • Product List

    S. No Product Name Dosage Form Strength
    1 Amphotericin – B Liposomal Lyophilized liposomal powder for injection 50mg/vial
    2 Albumin bound Paclitaxel nanoparticle Lyophilized nanoparticle for injection 100mg/vial
    3 PEGASPARAGASE Liquid injection & lyophilized injection 3750 IU/vial
    4 Leuprolite Acetate for depot suspension Microsphere for injection
    (Lyophilizate for suspension for infusion)
    3.75mg/vial, 7.5mg/vial,
    11.25 mg/vial
    5 Octreotide Microsphere for injection
    (Lyophilizate for suspension for infusion)
    10mg/vial, 20mg/vial, 30mg/vial
    6 Bupivacaine Liposomal Injectable Suspension Liposome for injection 133mg/vial & 266mg/vial