This blog discusses the use of human serum albumin as a drug delivery tool to improve the characteristics of drugs like paclitaxel. Albumin is highly soluble in hydrophobic drugs like paclitaxel and can be transported across blood vessels via the gp60 albumin receptor. Nanotechnology holds significant potential in pharmaceutical applications, especially in drug delivery, as nanomaterials enable efficient administration, protection, and transport of therapeutic agents. Solvent-based Paclitaxel (PTX) is a crucial chemotherapeutic agent used to treat lung, breast cancer, and AIDS-related Kaposi’s sarcoma. Non-toxic nano-delivery systems can protect the drug, lower toxicity, increase circulation half-life, improve pharmacokinetic profiles, and reduce side effects. Nab-paclitaxel, a solvent-free formulation, has shown superior transport across endothelial cells and enhanced extravascular distribution in patients.